And then there’s Janice Rogers Brown. Born to a farming family in Alabama in the heart of the Jim Crow years, Brown was originally a fairly progressive Democrat, inspired to go into law by the civil rights movement. But things changed. In 2003, a meta analysis of 12 trials indicated that vitamin E supplements did not provide benefit in cardiovascular death or cerebrovascular events.5 Instead, it showed that carotene supplementation led to a small increase in all cause mortality and cardiovascular death. In 2006, Flores Mateo et al reported that the use of supplements containing selenium did not reduce the risk of coronary heart disease in the meta analysis of six trials.6 More recently, however, Lee et al found that folic acid supplementation with B vitamins had potential small benefits in the prevention of stroke,7 and Qin et al indicated that folic acid treatment decreased the risk of cardiovascular disease by 15% in patients with end stage renal disease or advanced chronic kidney disease.8 Even though several meta analyses of randomised controlled trials have been published regarding the efficacy of vitamins and antioxidant supplements on cardiovascular diseases, they involved individual vitamins or antioxidants, and there was no published comprehensive meta analysis that reviewed this topic all together in one report. To the best of our knowledge, no meta analyses have performed subgroup analyses by important factors such as methodological quality or funding source.
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